A 45-year-old woman with a 15-year history of type 2 diabetes mellitus and hypertension is referred to nephrology clinic. On physical examination, temperature is 36.5℃, blood pressure is 150/90 mmHg, and pulse is 80/min. Cardiopulmonary examination is normal. She has 1+ ankle edema. She had microalbuminuria 5 years ago but now has 2+ proteinuria on urine dipstick. Her medications are amlodipine, flosemide, simvastatin and insulin.