We are pleased to bring you our 2012 Journal Watch Hospital Medicine Top Stories.As in previous years,our list focuses on inpatient topics,such as venous thromboembolism prophylaxis and treatment,Clostridium difficile infections,and transitions of care.However,the biggest stories of the year,in our opinion,relate to use and management of medications.Our ability to treat disease effectively is only as good as the safety of the drugs we administer.Equally important is the realization that drugs touted as the latest and greatest should always be viewed with caution until robust evidenc